Development of a Dual-Fluorescent-Reporter System in Clostridioides difficile Reveals a Division of Labor between Virulence and Transmission Gene Expression
Journal article published in 2022 by
M. Lauren Donnelly,
Shailab Shrestha,
John W. Ribis,
Pola Kuhn,
Maria Krasilnikov 
,
Carolina Alves Feliciano,
Aimee Shen
,
Carolina Alves Feliciano,
Aimee Shen
This paper is made freely available by the publisher.
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Abstract
Clostridioides difficile is an important nosocomial pathogen that causes severe diarrhea by producing toxins and transmits disease by producing spores. While both processes are crucial for C. difficile disease, only a subset of cells express toxins and/or undergo sporulation.