Published in
American Society for Microbiology, Microbiology Spectrum, 3(10), 2022
DOI: 10.1128/spectrum.01538-22
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Trivalent NDV-HXP-S Vaccine Protects against Phylogenetically Distant SARS-CoV-2 Variants of Concern in Mice
Journal article published in 2022 by
Irene González-Domínguez 
,
Jose Luis Martínez,
Stefan Slamanig ,
Nicholas Lemus,
Yonghong Liu,
Tsoi Ying Lai,
Juan Manuel Carreño,
Gagandeep Singh ,
G. Singh,
Michael Schotsaert,
Ignacio Mena,
Stephen McCroskery,
Lynda Coughlan ,
Florian Krammer ,
Adolfo García-Sastre
and other authors.
,
Jose Luis Martínez,
Stefan Slamanig ,
Nicholas Lemus,
Yonghong Liu,
Tsoi Ying Lai,
Juan Manuel Carreño,
Gagandeep Singh ,
G. Singh,
Michael Schotsaert,
Ignacio Mena,
Stephen McCroskery,
Lynda Coughlan ,
Florian Krammer ,
Adolfo García-Sastre
and other authors.
This paper is made freely available by the publisher.
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Abstract
This manuscript describes an extended work on the Newcastle disease virus (NDV)-based vaccine focusing on multivalent formulations of NDV vectors expressing different prefusion-stabilized versions of the spike proteins of different SARS-CoV-2 variants of concern (VOC). We demonstrate here that this low-cost NDV platform can be easily adapted to construct vaccines against SARS-CoV-2 variants.