Abstract Cancer is the result of a complex interplay of genetic, environmental, host, and societal factors operating over a prolonged time. The development of novel molecular technologies and informatics tools can facilitate a more comprehensive study of the risk factors contributing to the development of and outcomes from cancer in population studies. The National Cancer Institute (NCI) leads two programs in this area: the Innovative Molecular Analysis Technologies (IMAT) Program and the Informatics Technology for Cancer Research (ITCR) Program. IMAT supports the development, technical maturation, and dissemination of novel and potentially transformative next-generation technologies. ITCR program supports research-driven informatics technology development spanning all aspects of cancer research and stages of tool development, from algorithm development to prototyping, enhancement, and sustainment of these tools. The funding opportunities through these programs can support the development and application of new technologies for epidemiology research. For example, molecular technologies may address needs in areas such as exposure assessment, epigenetics, genomics, transcriptomics, imaging, and collection of biospecimens. Informatics technology needs may include genomic tools for data analysis, interpretation and visualization, annotation of genetic variants, supporting sharing of data, natural language processing of electronic health records (EHRs), managing cohort data collection, data harmonization, and extracting unstructured phenotype data from medical records. Importantly, the tools and resources that have been developed through these programs can be leveraged for use by epidemiology researchers. Learn more about the funding opportunities and technologies developed through these programs at https://imat.cancer.gov and https://itcr.cancer.gov. Citation Format: Leah E. Mechanic, Danielle M. Carrick, Tony Dickherber, Juli Klemm, NCI Innovative Molecular Analysis Technologies (IMAT) Program, NCI Informatics Technology for Cancer Research (ITCR) Program. NCI programs supporting technology development for population studies in digital age [abstract]. In: Proceedings of the AACR Special Conference on Modernizing Population Sciences in the Digital Age; 2019 Feb 19-22; San Diego, CA. Philadelphia (PA): AACR; Cancer Epidemiol Biomarkers Prev 2020;29(9 Suppl):Abstract nr A04.