Published in
Humana Press, Methods in Molecular Biology, p. 187-207
DOI: 10.1007/978-1-62703-218-6_16
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Identifying source proteins for MHC class I-presented peptides.
Book chapter published in 2012 by
Nathalie Vigneron,
Wenbin Ma,
Alexandre Michaux,
Benoît J. Van den Eynde
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Abstract
Identification of antigenic peptides recognized by cytolytic T lymphocytes (CTL) is a prerequisite for the development of targeted cancer immunotherapy approaches. This chapter provides a global approach for the identification of peptides recognized by CTL. It implies the identification of the HLA molecule presenting the peptide as well as the design and screening of a cDNA library derived from the tumor cells.