Published in
American Society for Microbiology, Microbiology Spectrum, 4(10), 2022
DOI: 10.1128/spectrum.00583-22
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A Structurally Characterized Staphylococcus aureus Evolutionary Escape Route from Treatment with the Antibiotic Linezolid
Journal article published in 2022 by
Laura Perlaza-Jiménez,
Kher-Shing Tan,
Sarah J. Piper,
Rachel M. Johnson,
Rebecca S. Bamert,
Christopher J. Stubenrauch 
,
Alexander Wright,
David Lupton,
Trevor Lithgow ,
Matthew J. Belousoff
,
Alexander Wright,
David Lupton,
Trevor Lithgow ,
Matthew J. Belousoff
This paper is made freely available by the publisher.
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Abstract
Antibiotic resistance poses a critical problem to human health and decreases the utility of these lifesaving drugs. Of particular concern is the “superbug” methicillin-resistant Staphylococcus aureus (MRSA), for which treatment of infection requires the use of last-line antibiotics, including linezolid.