BackgroundCeliac disease (CD) is one of the most common gastrointestinal tract diseases, in adults and children. Prevalence of CD is 1-3% [2]. The most common symptoms of CD are gastrointestinal symptoms. At the same time, celiac disease may manifest with extraintestinal symptoms, including the musculoskeletal, nervous, reproductive system, and skin, especially when it debuts at a late age [1,2]. However, data about musculoskeletal manifestations of CD are limited.ObjectivesTo show the frequency of musculoskeletal complaints and their peculiarities in patients with CD.MethodsData from 94 patients with diagnosed by gastroenterologist celiac disease were collected with the on-lain survey. All the patients were positive in CD-related immunological and genetic tests and had biopsy established CD.ResultsТhe average age of respondents is 37,52 ± 11,2 years, women 79 (84,1%), men 15 (15,9%). Among 94 respondents 0.1% do not follow a gluten-free diet, 10.6% <1 year, 25.5% from 1 to 3 years, 11.7% – 4-5 years, 28.7% are on a gluten-free diet >5 years, 14.9% – 10-15 years, 8.5% > 15 years. Gastrointestinal symptoms have started at the age < 10 years old in 59.6% of patients, in 4.2% in 11-16 years old, 13.8% at the age 17-25 years old, 12.8% at the age 26-40 years old, 9.6% had late CD onset (>40 years old).Extraintestinal symptoms such as drowsiness were noted by 46.8 %, headaches by 40.4%, weakness by 59.6%, irritability by 57.4% of respondents. Lack of coordination was noticed in 18.1% of cases, dizziness in 22.3%, 57.4% have numbness, decreased sensitivity, and tingling feeling in the limbs. Joint pain had 54.3% of the patients with CD (Figure 1).Figure 1.Frequency of pain in different jointsThe maximal intensity of pain was noticed in the morning (8.5%) or late night (13.8%) times and fulfilled inflammatory pain criteria (ASAS). In 17% was noticed interrelation between gluten-free diet violation and the appearance of joint pain. In 26.6% was noticed signs of enthesitis. Weakness of arms was noticed by 39.4% of respondents. Non-steroidal anti-inflammatory drugs (NSAIDs) were started by 35.1% of patients, without any improvement in 66% of cases.ConclusionPatients’ surveys showed that musculoskeletal symptoms in patients with celiac disease are not a rare problem and they are comparable with the frequency of neurological symptoms. Additional research is necessary for a better understanding of the nature of musculoskeletal involvement in celiac disease.References[1]Admou, B., et al. https://doi.org/10.1155/2012/637187.[2]Laurikka P., et al. https://doi.org/10.3390/nu10081015Disclosure of InterestsNone declared