Published in
American Society for Microbiology, Microbiology Spectrum, 4(10), 2022
DOI: 10.1128/spectrum.01288-22
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Unveiling the Biosynthetic Pathway for Short Mycolic Acids in Nontuberculous Mycobacteria: Mycobacterium smegmatis MSMEG_4301 and Its Ortholog Mycobacterium abscessus MAB_1915 Are Essential for the Synthesis of α′-Mycolic Acids
Journal article published in 2022 by
Cecilia B. Di Capua,
Juan M. Belardinelli 
,
Hugo A. Carignano,
María V. Buchieri,
Cristian A. Suarez,
Héctor R. Morbidoni
,
Hugo A. Carignano,
María V. Buchieri,
Cristian A. Suarez,
Héctor R. Morbidoni
This paper is made freely available by the publisher.
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Abstract
Mycobacterium abscessus is a nontuberculous mycobacterium responsible for an increasing number of hard-to-treat infections due to the impervious nature of its cell envelope, a natural barrier to several antibiotics. Mycolic acids are key components of that envelope; thus, their synthesis is a valuable target for drug development.