The investigation studied the effects of 0.2 wt.% and 1 wt.% scandium (Sc) additions on the microstructure of the aluminium alloy AA 6086 in different conditions. The alloys were produced by casting into a metallic mould, followed by various heat treatments. The alloys were examined using light microscopy, scanning and transmission electron microscopy, microchemical analysis, differential scanning calorimetry and X-ray diffraction. The phase compositions and solidification sequences were modelled using the CALPHAD approach, which reasonably agreed with the experimental results. The addition of Sc to AA 6086 strongly reduced the grain size of the Al-rich solid solution and induced the appearance of Sc-rich phases AlSc2Si2 and L12-Al3X. Other phases identified in the Sc-free alloy were also found in the Sc-modified alloys. Homogenisation caused the dissolution of most phases and the formation of different types of dispersoids. In the alloy with 0.2% Sc, the distribution of dispersoids was not uniform. The plate-like AlMnCrSi dispersoids formed mainly at the dendrite centres, together with spherical L12 precipitates, while smaller α-AlMnSi and tetragonal t-Al3Zr dispersoids were created elsewhere. The addition of 0.2% Sc did not considerably affect the strengthening of AA 6086. The precipitation during isothermal ageing was slightly delayed and shifted to higher temperatures during continuous heating.