Published in
Royal Society of Chemistry, Chemical Science, 33(13), p. 9507-9514, 2022
DOI: 10.1039/d2sc02871a
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Hexafluoroisobutylation of enolates through a tandem elimination/allylic shift/hydrofluorination reaction
Journal article published in 2022 by
Aline Delamare,
Guillaume Naulet,
Brice Kauffmann 
,
Gilles Guichard ,
Guillaume Compain
,
Gilles Guichard ,
Guillaume Compain
This paper is made freely available by the publisher.
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Abstract
Hexafluoroisobutylation of ketoesters, malonates, diketones, Schiff base esters and malononitrile is reported. The reaction involves an elimination/allylic shift/hydrofluorination cascade process that efficiently overcomes the usual SN2′ mechanism.