Digital game-based learning (DGBL) is a novel methodology implemented in many educational virtual settings to improve students´ attention, motivation, and engagement while learning. This chapter aims to provide insight into how game-based methods can enhance students' learning process with sensory, intellectual, and learning disabilities. Specifically, the key of this chapter is to assess the possibilities offered by the introduction of DGBL in educational contexts from a theoretical perspective to understand better the range of opportunities that it can mean for learning and, therefore, for the personal and professional development of people with sensory, intellectual, and learning disabilities.