Building performant and robust artificial intelligence (AI)–based applications for dentistry requires large and high-quality data sets, which usually reside in distributed data silos from multiple sources (e.g., different clinical institutes). Collaborative efforts are limited as privacy constraints forbid direct sharing across the borders of these data silos. Federated learning is a scalable and privacy-preserving framework for collaborative training of AI models without data sharing, where instead the knowledge is exchanged in form of wisdom learned from the data. This article aims at introducing the established concept of federated learning together with chances and challenges to foster collaboration on AI-based applications within the dental research community.