Dissemin is shutting down on January 1st, 2025

Published in

MDPI, Genes, 8(13), p. 1378, 2022

DOI: 10.3390/genes13081378

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The Contribution of Genetics to Muscle Disuse, Retraining, and Aging

This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Genetic background may partly explain differences in muscle responses to internal or external stimuli. Muscle disuse involves various degrees of skeletal muscle atrophy due to inactivity and mechanical unloading. Whether and to which extent genetic background impacts disuse atrophy and retraining in individuals of different ages are currently unclear. Here, we provide a brief overview of relevant literature on the contribution of genetics to muscle disuse, retraining, and aging, and offer a perspective on unanswered questions on the subject that may open new venues for research.