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BMJ Publishing Group, Journal of Neurology, Neurosurgery and Psychiatry, 4(78), p. 417-418

DOI: 10.1136/jnnp.2006.102517

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Epidemiology of myasthenia gravis with anti‐muscle specific kinase antibodies in the Netherlands

Journal article published in 2006 by Erik H. Niks ORCID, Jan B. M. Kuks, Jan J. G. M. Verschuuren
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This paper is available in a repository.

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Abstract

The epidemiology of myasthenia gravis subtypes and the frequency of antibodies to muscle‐specific kinase (MuSK) was studied in patients with generalised myasthenia gravis without anti‐acetylcholine receptor antibodies who had an onset of symptoms between 1990 and 2004 in a well‐defined region in the Netherlands. The nationwide prevalence and incidence of myasthenia gravis with anti‐MuSK antibodies were also studied. MuSK antibodies were found in 22% of patients with generalised myasthenia gravis without anti‐acetylcholine receptor antibodies. Nationwide, 35 patients with MuSK myasthenia gravis were identified, yielding a prevalence of 1.9 per million (95% confidence interval (CI) 1.22 to 2.59) and an annual incidence 0.10 per million person‐years (95% CI 0.06 to 0.14).