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American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 11(58), p. 6958-6961, 2014

DOI: 10.1128/aac.03323-14

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Plasmodium falciparum and Plasmodium vivax genotypes and efficacy of intermittent preventive treatment in Papua New Guinea

Journal article published in 2014 by Celine Barnadas, Nicolas Senn, Jonah Iga, Lincoln Timinao, Sarah Javati, Elisheba Malau, Patricia Rarau, John C. Reeder, Peter Siba, Harin Karunajeewa, Peter A. Zimmerman, Timothy M. Davis ORCID, Ivo Mueller
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

ABSTRACT Intermittent preventive treatment of infants (IPTi) reduces early childhood malaria-related morbidity. While genotypic drug resistance markers have proven useful in predicting the efficacy of antimalarial drugs in case management, there are few equivalent data relating to their protective efficacy when used as IPTi. The present data from an IPTi trial in Papua New Guinea demonstrate how these markers can predict protective efficacy of IPTi for both Plasmodium falciparum and Plasmodium vivax .