AbstractPsychological stress is the most commonly self‐reported precursor of epileptic seizures. However, retrospective and prospective studies remain inconclusive in this regard. Here, we explored whether seizures would be preceded by significant changes in reported stressors or resource utilization. This study is based on high‐frequency time series through daily online completion of personalized questionnaires of 9–24 items in epilepsy outpatients and compared responses 1–14 days before seizures with interictal time series. Fourteen patients (79% women, age = 23–64 years) completed daily questionnaires over a period of 87–898 days (median = 277 days = 9.2 months). A total of 4560 fully completed daily questionnaires were analyzed, 685 of which included reported seizure events. Statistically significant changes in preictal compared to interictal dynamics were found in 11 of 14 patients (79%) across 41 items (22% of all 187 items). In seven of 14 patients (50%), seizures were preceded by a significant mean increase of stressors and/or a significant mean decrease of resource utilization. This exploratory analysis of long‐term prospective individual patient data on specific stressors and personal coping strategies generates the hypothesis that medium‐term changes in psychological well‐being may precede the occurrence of epileptic seizures in some patients.