American Society of Clinical Oncology, Journal of Clinical Oncology, 16_suppl(40), p. e19529-e19529, 2022
DOI: 10.1200/jco.2022.40.16_suppl.e19529
Elsevier, Clinical Lung Cancer, 8(23), p. e510-e518, 2022
DOI: 10.1016/j.cllc.2022.08.003
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e19529 Background: There is insufficient data regarding the incidence rate of secondary lung cancer among Hodgkin lymphoma survivors and the predisposing factors. Methods: We analyzed the data from the cohort of subjects who had Hodgkin Lymphoma between 1973 and 2015 using the Surveillance Epidemiology and End Results database (SEER). Data on patient's age, gender, year of diagnosis with Hodgkin lymphoma, Ann-Arbor stage, Histology, racial groups, date of last follow-up, date of death, and treatment modalities were collected. Results: We identified a total of 56,856 subjects with Hodgkin lymphoma; of those, 862 had secondary lung cancer, with an incidence rate of 157 (95%CI: 147-168) per 100,000 person-years. The median overall survival from time of Hodgkin Lymphoma diagnosis for those with secondary lung cancer was 12.1 years (95%CI: 10.7-13) compared to 27.1 years (95%CI: 26.5-27.6) for those who did not develop lung cancer. After propensity score weighting, radiation therapy was associated with a higher risk of secondary lung cancer (HR: 1.23, 95%CI: 1.002-1.55). Older age at the time of Hodgkin lymphoma diagnosis and male gender were associated with higher risk, with an HR of 1.07 (95%CI 1.062-1.073) and an HR of 1.602 (95%CI 1.33-1.94), respectively. Furthermore, chemotherapy increases the risk only among older age groups. Conclusions: Older age at the time of Hodgkin Lymphoma diagnosis, male gender, radiation therapy and chemotherapy only among older age groups were associated with higher risk for secondary lung cancer, with 50% of the cases occurring within 9.1 years following Hodgkin lymphoma diagnosis.[Table: see text]