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BioMed Central, Molecular Cancer, 1(14), 2015

DOI: 10.1186/s12943-015-0316-2

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High MACC1 expression in combination with mutated KRAS G13 indicates poor survival of colorectal cancer patients

Journal article published in 2015 by Katharina Ilm, Wolfgang Kemmner, Marc Osterland, Susen Burock ORCID, Gudrun Koch, Pia Herrmann, Schlag Pm, Peter M. Schlag, Ulrike Stein
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Abstract Background The metastasis-associated in colon cancer 1 (MACC1) gene has been identified as prognostic biomarker for colorectal cancer (CRC). Here, we aimed at the refinement of risk assessment by separate and combined survival analyses of MACC1 expression with any of the markers KRAS mutated in codon 12 (KRAS G12) or codon 13 (KRAS G13), BRAF V600 mutation and MSI status in a retrospective study of 99 CRC patients with tumors UICC staged I, II and III. Findings We showed that only high MACC1 expression (HR: 6.09, 95% CI: 2.50-14.85, P