Published in
American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 9(66), 2022
DOI: 10.1128/aac.00592-22
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Moxifloxacin-Mediated Killing of Mycobacterium tuberculosis Involves Respiratory Downshift, Reductive Stress, and Accumulation of Reactive Oxygen Species
Journal article published in 2022 by
Somnath Shee,
Samsher Singh 
,
Ashutosh Tripathi,
Chandrani Thakur,
Anand Kumar T.,
Mayashree Das,
Vikas Yadav,
Sakshi Kohli,
Raju S. Rajmani,
Nagasuma Chandra ,
Harinath Chakrapani,
Karl Drlica,
Amit Singh
,
Ashutosh Tripathi,
Chandrani Thakur,
Anand Kumar T.,
Mayashree Das,
Vikas Yadav,
Sakshi Kohli,
Raju S. Rajmani,
Nagasuma Chandra ,
Harinath Chakrapani,
Karl Drlica,
Amit Singh
This paper is made freely available by the publisher.
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Abstract
Moxifloxacin is central to treatment of multidrug-resistant tuberculosis. Effects of moxifloxacin on the Mycobacterium tuberculosis redox state were explored to identify strategies for increasing lethality and reducing the prevalence of extensively resistant tuberculosis.