Published in
American Society for Microbiology, Microbiology Spectrum, 5(10), 2022
DOI: 10.1128/spectrum.01686-22
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Dose-Dependent Hepacivirus Infection Reveals Linkage between Infectious Dose and Immune Response
Journal article published in 2022 by
André Gömer 
,
Julien Delarocque ,
Christina Puff,
Maximilian K. Nocke ,
Birthe Reinecke,
Wolfgang Baumgärtner,
Jessika M. V. Cavalleri,
Karsten Feige,
Eike Steinmann ,
Daniel Todt
,
Julien Delarocque ,
Christina Puff,
Maximilian K. Nocke ,
Birthe Reinecke,
Wolfgang Baumgärtner,
Jessika M. V. Cavalleri,
Karsten Feige,
Eike Steinmann ,
Daniel Todt
This paper is made freely available by the publisher.
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Abstract
We demonstrate that the EqHV dose of infection plays an important role for inducing immune responses, possibly linked to early clearance in high-dose and prolonged viremia in low-dose infections. In particular, pathways associated with innate and adaptive immune responses, as well as inflammatory responses, were more strongly upregulated in high-dose infections than in lower doses.