Published in
Public Library of Science, PLoS ONE, 10(5), p. e13376, 2010
DOI: 10.1371/journal.pone.0013376
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- [www.ncbi.nlm.nih.gov] | PDF
- [www.ncbi.nlm.nih.gov] | PDF
- [europepmc.org] | PDF
- [dash.harvard.edu] | PDF
- [epubs.surrey.ac.uk] | PDF
- [epubs.surrey.ac.uk] | PDF
- [www.zora.uzh.ch] | PDF
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The physiological period length of the human circadian clock in vivo is directly proportional to period in human fibroblasts
Journal article published in 2010 by
Lucia Pagani,
Ermanno Moriggi,
Ekaterina A. Semenova,
Lisa M. Hack,
Victoria L. Revell,
Josephine Arendt,
Steven W. Lockley,
Debra J. Skene 
,
Fides Meier,
Jan Izakovic,
Anna Wirz-Justice,
Christian Cajochen,
Oksana J. Sergeeva,
Sergei V. Cheresiz,
Konstantin V. Danilenko
and other authors.
,
Fides Meier,
Jan Izakovic,
Anna Wirz-Justice,
Christian Cajochen,
Oksana J. Sergeeva,
Sergei V. Cheresiz,
Konstantin V. Danilenko
and other authors.
This paper is made freely available by the publisher.
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Abstract
Diurnal behavior in humans is governed by the period length of a circadian clock in the suprachiasmatic nuclei of the brain hypothalamus. Nevertheless, the cell-intrinsic mechanism of this clock is present in most cells of the body. We have shown previously that for individuals of extreme chronotype ("larks" and "owls"), clock properties measured in human fibroblasts correlated with extreme diurnal behavior.