Abstract Protostellar outflows are one of the most outstanding features of star formation. Observational studies over the last several decades have successfully demonstrated that outflows are ubiquitously associated with low- and high-mass protostars in solar-metallicity Galactic conditions. However, the environmental dependence of protostellar outflow properties is still poorly understood, particularly in the low-metallicity regime. Here we report the first detection of a molecular outflow in the Small Magellanic Cloud with 0.2 Z _⊙, using Atacama Large Millimeter/submillimeter Array observations at a spatial resolution of 0.1 pc toward the massive protostar Y246. The bipolar outflow is nicely illustrated by high-velocity wings of CO(3–2) emission at ≳15 km s⁻¹. The evaluated properties of the outflow (momentum, mechanical force, etc.) are consistent with those of the Galactic counterparts. Our results suggest that the molecular outflows, i.e., the guidepost of the disk accretion at the small scale, might be universally associated with protostars across the metallicity range of ∼0.2–1 Z _⊙.