Published in
Royal Society of Chemistry, RSC Chemical Biology, 10(3), p. 1216-1229, 2022
DOI: 10.1039/d2cb00161f
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The covalent reactivity of functionalized 5-hydroxy-butyrolactams is the basis for targeting of fatty acid binding protein 5 (FABP5) by the neurotrophic agent MT-21
Journal article published in 2022 by
Esben Bjerregaard Svenningsen 
,
Rasmus Nørbøge Ottosen,
Katrine Harpøth Jørgensen,
Marija Nisavic ,
Camilla Kjeldgaard Larsen,
Bente Kring Hansen,
Yong Wang ,
Kresten Lindorff-Larsen ,
Thomas Tørring,
Stephan M. Hacker ,
Johan Palmfeldt,
Thomas B. Poulsen
,
Rasmus Nørbøge Ottosen,
Katrine Harpøth Jørgensen,
Marija Nisavic ,
Camilla Kjeldgaard Larsen,
Bente Kring Hansen,
Yong Wang ,
Kresten Lindorff-Larsen ,
Thomas Tørring,
Stephan M. Hacker ,
Johan Palmfeldt,
Thomas B. Poulsen
This paper is made freely available by the publisher.
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Abstract
In this work, it is shown that an N-acyl hemiaminal motif present in many natural products can function as an electrophilic centre, mediating covalent reactivity in biological systems, reacting with both thiols and amines.