American Society for Microbiology, Microbiology Spectrum, 5(10), 2022
DOI: 10.1128/spectrum.02141-22
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Plasmodium sexual stages represent a critical bottleneck in the parasite life cycle. Gametocytes taken up in an infectious blood meal by female anopheline mosquito get activated to form gametes and fuse to form short-lived zygotes, which transform into ookinetes to infect mosquitoes.