Immune Imprinting Drives Human Norovirus Potential for Global Spread
Journal article published in 2022 by
Lisa C. Lindesmith 
,
Florencia A. T. Boshier,
Paul D. Brewer-Jensen,
Sunando Roy,
Veronica Costantini,
Michael L. Mallory,
Mark Zweigart,
Samantha R. May,
Helen Conrad,
Kathleen M. O’Reilly,
Daniel Kelly,
Cristina C. Celma,
Stuart Beard,
Rachel Williams,
Helena J. Tutill
and other authors.
,
Florencia A. T. Boshier,
Paul D. Brewer-Jensen,
Sunando Roy,
Veronica Costantini,
Michael L. Mallory,
Mark Zweigart,
Samantha R. May,
Helen Conrad,
Kathleen M. O’Reilly,
Daniel Kelly,
Cristina C. Celma,
Stuart Beard,
Rachel Williams,
Helena J. Tutill
and other authors.
This paper is made freely available by the publisher.
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Abstract
In our model, preepidemic human norovirus variants harbor genetic diversification that translates into novel antigenic features without compromising viral fitness. Through surveillance, we identified two viruses fitting this profile, forming long branches on a phylogenetic tree.