American Society for Cell Biology, Molecular Biology of the Cell, 14(33), 2022
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Yeast cells lacking the Cox12 subunit of Cytochrome c (CcO) oxidase are impaired in mitochondrial respiration. With a combination of experimental evolution, genetics, and biochemistry, we prove that elimination of the PSI+ prion improves CcO oxidase activity and respiratory metabolism in strains lacking Cox12.