Published in
American Society for Microbiology, Microbiology Spectrum, 5(10), 2022
DOI: 10.1128/spectrum.02551-22
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A High Daptomycin Dose Is Associated with Better Bacterial Clearance in Infections Caused by Vancomycin-Resistant Enterococcus faecium Regardless of Daptomycin Minimum Inhibitory Concentration in a Rat Infective Endocarditis Model
Journal article published in 2022 by
Jann-Tay Wang,
Chia-Jui Yang,
Jia-Ling Yang,
Shu-Wen Lin,
Yu-Chung Chuang 
,
Wang-Huei Sheng,
Yee-Chun Chen,
Shan-Chwen Chang
,
Wang-Huei Sheng,
Yee-Chun Chen,
Shan-Chwen Chang
This paper is made freely available by the publisher.
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Abstract
Using a rat IE model with pharmacokinetic analysis, the treatment response of VREf IE was found to be daptomycin dose-dependent, presented as Cmax /MIC or as the 24 h area under the concentration-time curve (AUC 0–24 )/MIC. Daptomycin 90 mg/kg s.c. significantly reduced the bacterial load against DSE and DNSE.