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Royal Society of Chemistry, Chemical Science, 43(13), p. 12713-12725, 2022

DOI: 10.1039/d2sc03928a

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A rotaxane-based platform for tailoring the pharmacokinetics of cancer-targeted radiotracers

Journal article published in 2022 by Faustine d'Orchymont ORCID, Jason P. Holland ORCID
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Mechanically interlocked rotaxanes are transformed into positron-emitting radiotracers for cancer biomarker imaging. Mechanical bonding offers new possibilities for controlling drug delivery, metabolism, and excretion profiles in vivo.