Antibiotic Acyldepsipeptides Stimulate the Streptomyces Clp-ATPase/ClpP Complex for Accelerated Proteolysis
Journal article published in 2022 by
Peter Sass 
,
Linda Maria Westermann,
Laura Reinhardt,
Dhana Thomy,
Markus Lakemeyer,
Joaquin Ortega,
Sieber Sa,
Stephan A. Sieber ,
Heike Brötz-Oesterhelt
,
Linda Maria Westermann,
Laura Reinhardt,
Dhana Thomy,
Markus Lakemeyer,
Joaquin Ortega,
Sieber Sa,
Stephan A. Sieber ,
Heike Brötz-Oesterhelt
This paper is made freely available by the publisher.
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Abstract
Clp proteases are antibiotic and anticancer drug targets. Composed of the proteolytic core ClpP and a regulatory Clp-ATPase, the protease machinery is important for protein homeostasis and regulatory proteolysis.