Metal nanoparticles use a biocompatible, environmentally sustainable approach to be used as therapeutic nanomedicine. This study describes the use of rosaceous fruit peel waste extract (plum, kiwi, peach) as a tool for the synthesis of silicon nanoparticles. Visual color shift was used to identify biosynthesized SiO₂NPs at first. Some characterization techniques, such as X-ray diffraction (XRD), Fourier transform infrared (FT-IR) and SEM analysis, verified the existence of these metal nanoparticles. The presence of various functional groups from the extract secondary metabolites for nanoparticle synthesis is suggested by FT-IR spectroscopy. The existence of SiO₂ nanoparticles, whether crystalline or amorphous, is hypothesized using XRD. The formation of SiO₂ nanoparticles was confirmed by UV–Vis spectroscopy. The zeta potential shows the nanoparticles stability. Different fruits peels produced different shapes and sizes of SiO₂NPs. Plum peels extract produced the smallest SiO₂NPs, followed by kiwi and peach as determined by SEM analysis. Antibacterial and antioxidant activities were also tested on all of the synthesized SiO₂NPs. Regardless of size; these nanoparticles have stronger antibacterial activity against gram-negative bacteria. All SiO₂NPs’ antioxidant activity was measured in a size and dose-dependent manner. To summarize, the current environmentally friendly method for the synthesis of SiO₂NPs nanoparticles is a simple and economical process with good antibacterial and antioxidant properties.