Maxillofacial reconstructions with free grafts have become a routine reality for plastic surgeons and maxillofacial surgeons in the last decade. This condition usually occurs after radical treatment of benign or malignant pathologies of the stomatognathic complex, through en bloc resections with a safety margin to reduce the chances of recurrence of the pathology. One of the great challenges faced by surgical teams is no longer just in relation to the technique used for planning, but the predictability and maintenance of the graft performed in the face of systemic changes that can compromise the success of the graft, such as diabetes mellitus. Several aspects have been explored in recent years, such as the use of ozone, synthetic membranes, formation of Leukocyte and Platelet Rich Fibrin (L-PRF) and hyperbaric therapy in the quest to maximize the chances of graft success, reducing the chances of infection and bone resorption mainly through osteoinductive and osteogenic stimuli, which are not characteristics present in a metabolic dysfunction such as diabetes. Another important data for these types of surgery is the bone quality offered by the donor bed, because in maxillofacial reconstructions, a balance in the amount of corticalized bone and medullary bone is important, which leads us to characteristics such as the best donor bed for these surgical reconstructions in the iliac crest region. Here the authors present a case of 64 years old male hypertensive patient with h/o diabetes mellitus, managed by a mandibular reconstruction surgery with iliac crest graft associated with L-PRF and hyperbaric oxygen therapy after extensive resection of a benign mandibular tumour in a patient with diabetes mellitus.