Published in
American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 12(66), 2022
DOI: 10.1128/aac.01001-22
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A Novel Ex Vivo Drug Assay for Assessing the Transmission-Blocking Activity of Compounds on Field-Isolated Plasmodium falciparum Gametocytes
Journal article published in 2022 by
Dinkorma T. Ouologuem 
,
Laurent Dembele ,
Antoine Dara,
Aminatou K. Kone,
Nouhoum Diallo,
Cheick P. O. Sangare,
Fatoumata I. Ballo,
François Dao,
Siaka Goita,
Aboubecrin S. Haidara,
Aliou Traore,
Amadou B. Niangaly,
Souleymane Dama,
Sekou Sissoko,
Fanta Sogore
and other authors.
,
Laurent Dembele ,
Antoine Dara,
Aminatou K. Kone,
Nouhoum Diallo,
Cheick P. O. Sangare,
Fatoumata I. Ballo,
François Dao,
Siaka Goita,
Aboubecrin S. Haidara,
Aliou Traore,
Amadou B. Niangaly,
Souleymane Dama,
Sekou Sissoko,
Fanta Sogore
and other authors.
This paper is made freely available by the publisher.
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Abstract
The discovery and development of transmission-blocking therapies challenge malaria elimination and necessitate standard and reproducible bioassays to measure the blocking properties of antimalarial drugs and candidate compounds. Most of the current bioassays evaluating the transmission-blocking activity of compounds rely on laboratory-adapted Plasmodium strains.