Published in
Rockefeller University Press, Journal of Experimental Medicine, 1(220), 2022
DOI: 10.1084/jem.20221850
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Friend turned foe: TREM2 agonist in battles against tau
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Abstract
In this important study, Jain et al. (2022. J. Exp. Med.https://doi.org/10.1084/jem.20220654) find that chronic TREM2 activation by AL002a antibody exacerbates the seeding and spread of pathological tau, enhances the disease-associated microglial signature, and increases neurite dystrophy in 5xFAD mice seeded with Alzheimer’s disease tau.