Published in
American Society for Microbiology, Journal of Virology, 23(96), 2022
DOI: 10.1128/jvi.01250-22
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The P681H Mutation in the Spike Glycoprotein of the Alpha Variant of SARS-CoV-2 Escapes IFITM Restriction and Is Necessary for Type I Interferon Resistance
Journal article published in 2022 by
Maria Jose Lista,
Helena Winstone,
Harry D. Wilson 
,
Adam Dyer,
Suzanne Pickering,
Rui Pedro Galao,
Giuditta De Lorenzo ,
Vanessa M. Cowton,
Wilhelm Furnon,
Nicolas Suarez,
Richard Orton,
Massimo Palmarini,
Arvind H. Patel ,
Luke Snell ,
Gaia Nebbia
and other authors.
,
Adam Dyer,
Suzanne Pickering,
Rui Pedro Galao,
Giuditta De Lorenzo ,
Vanessa M. Cowton,
Wilhelm Furnon,
Nicolas Suarez,
Richard Orton,
Massimo Palmarini,
Arvind H. Patel ,
Luke Snell ,
Gaia Nebbia
and other authors.
This paper is made freely available by the publisher.
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Abstract
Accumulating evidence suggests that variants of concern (VOC) of SARS-CoV-2 evolve to evade the human immune response, with much interest focused on mutations in the spike protein that escape from antibodies. However, resistance to the innate immune response is essential for efficient viral replication and transmission.