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Elsevier, Nuclear Medicine and Biology, 8(31), p. 995-1003, 2004

DOI: 10.1016/j.nucmedbio.2004.08.008

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In Vivo Quantification of bound [123I]ADAM to Serotonin Transporters in the Brains of Rabbits by SPECT

Journal article published in 2004 by Xin-Xian Ye, Hwang JJ Shieh Jf Jc Chen YT Chou KY Tu Wey SP Ting G. Ye Xx, Jeng-Jong Hwang, Jih-Fang Hsieh, Jyh-Cheng Chen, Yueh-Ting Chou, Kao-Yin Tu, Shiaw-Pyng Wey, Gann Ting
This paper is available in a repository.
This paper is available in a repository.

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Abstract

A novel radioiodine ligand [123I] ADAM (2-((2-((dimethylamino)methyl)phenyl)thio)-5-iodophenylamine) has been suggested as a promising serotonin transporter (SERT) imaging agent for the central nervous system. In this study, the biodistribution of SERTs in the rabbit brain was investigated using [123I] ADAM and mapping images of the same animal produced by both single-photon emission computed tomography (SPECT) and microautoradiography. A semiquantification method was adopted to deduce the optimum time for SPECT imaging, whereas the input for a simple fully quantitative tracer kinetic model was provided from arterial blood sampling data.