Dissemin is shutting down on January 1st, 2025

Published in

Newlands Press, Pharmaceutical Patent Analyst, 1(12), p. 19-25, 2023

DOI: 10.4155/ppa-2022-0036

Links

Tools

Export citation

Search in Google Scholar

Co-processed tablet excipient composition, its preparation and use: US10071059 B2: patent spotlight

Journal article published in 2022 by Sajal Jain ORCID, Ritu Rathi ORCID, Upendra Nagaich ORCID, Inderbir Singh ORCID
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

Full text: Unavailable

Green circle
Preprint: archiving allowed
Green circle
Postprint: archiving allowed
Red circle
Published version: archiving forbidden
Data provided by SHERPA/RoMEO

Abstract

Co-processing involves the incorporation of one excipients into the particle structure of other excipients to overcome the deficiencies of each excipients. The current patent describes the co-processing of microcrystalline cellulose and mannitol via fluid bed agglomeration with an aim to limit the use of lubricant in tablet composition. The co-processed excipients blend was compared with the physical blend of excipients and characterized for scanning electron microscopy, disintegration and hardness. The average particle size of co-processed excipients was less than 0.55 mm, characterized by large individual lactose-coated particles whereas, the physical blend particles are uncoated and irregular in shape. Tablets made from both physical blend and co-processed excipients were compared. As per the hardness and disintegration studies, with increase in mixing time of excipients both hardness and disintegration time decreases.