Published in
American Society for Microbiology, Microbiology Spectrum, 6(10), 2022
DOI: 10.1128/spectrum.03422-22
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Influence of Sodium Bicarbonate on Wall Teichoic Acid Synthesis and β-Lactam Sensitization in NaHCO <sub>3</sub> -Responsive and Nonresponsive Methicillin-Resistant Staphylococcus aureus
Journal article published in 2022 by
Selvi C. Ersoy 
,
Barbara Gonçalves,
Gonçalo Cavaco,
Adhar C. Manna ,
Rita G. Sobral ,
Cynthia C. Nast,
Richard A. Proctor,
Henry F. Chambers,
Ambrose Cheung,
Arnold S. Bayer
,
Barbara Gonçalves,
Gonçalo Cavaco,
Adhar C. Manna ,
Rita G. Sobral ,
Cynthia C. Nast,
Richard A. Proctor,
Henry F. Chambers,
Ambrose Cheung,
Arnold S. Bayer
This paper is made freely available by the publisher.
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Abstract
MRSA is generally viewed as resistant to standard β-lactam antibiotics. However, a NaHCO 3 -responsive phenotype is observed in a substantial proportion of clinical MRSA strains in vitro , i.e., isolates which demonstrate enhanced susceptibility to standard β-lactam antibiotics (e.g., oxacillin) in the presence of NaHCO 3 .