The ESX-1 Substrate PPE68 Has a Key Function in ESX-1-Mediated Secretion in Mycobacterium marinum
Journal article published in 2022 by
Merel P. M. Damen 
,
Aniek S. Meijers,
Esther M. Keizer,
Sander R. Piersma,
Connie R. Jiménez,
Coenraad P. Kuijl ,
Wilbert Bitter,
Edith N. G. Houben
,
Aniek S. Meijers,
Esther M. Keizer,
Sander R. Piersma,
Connie R. Jiménez,
Coenraad P. Kuijl ,
Wilbert Bitter,
Edith N. G. Houben
This paper is made freely available by the publisher.
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Abstract
Pathogenic mycobacteria, suchMycobacterium tuberculosisandMycobacterium marinum, use a type VII secretion system (T7SS) subtype, called ESX-1, to mediate intracellular survival via phagosomal rupture and subsequent translocation of themycobacteriumto the host cytosol. Identifying the ESX-1 substrate that is responsible for this process is problematic because of the intricate network of codependent secretion between ESX-1 substrates.