In recent decades, patient safety in orthopedics has gained increasing importance and has been regarded as a core concept of medical care quality. However, according to currently published studies, measurement instruments used to evaluate post-surgery orthopedic patient’s perceptions are still very rare. This study aimed to develop a new measurement instrument, the self-perceived safety of orthopedic post-surgery inpatients (SPSOPSI) scale, which can provide healthcare workers with a better understanding of orthopedic patients’ self-perceived safety and give more precise clinical suggestions. Item analysis and exploratory factor analysis (EFA) were used, and the results showed that the six-factor model is good-fit: root mean square residual (RMR) 0.00, root mean square error of approximation (RMSEA) 0.06, goodness-of-fit index (GFI) 0.90, comparative fit index (CFI) 0.98, incremental fit index (IFI) 0.98. The results showed the SPSOPSI scale is a valid and reliable tool for health care providers can use to evaluate orthopedic post-surgery patients’ perceived safety.