Abstract. Increasing human activities along the coasts of the world provoke the necessity to assess tsunami hazard from different sources (earthquakes, landslides, volcanic activity). In this paper, we simulate tsunamis generated by underwater volcanic explosions from (1) a submerged vent in a shallow water lake (Karymskoye Lake, Kamchatka), and (2) from Kolumbo submarine volcano (7 km NE of Santorini, Aegean Sea, Greece). The 1996 tsunami in Karymskoye lake is a well-documented example and thus serves as a case study for validating the calculations. The numerical model reproduces realistically the tsunami run-ups measured onshore. Systematic numerical study of tsunamis generated by explosions of the Kolumbo volcano is then conducted for a wide range of energies. Results show that in case of reawakening, the Kolumbo volcano might represent a significant tsunami hazard for the northern, eastern and southern coasts of Santorini, even for small-power explosions.