Published in
American Society for Microbiology, Journal of Virology, 24(96), 2022
DOI: 10.1128/jvi.01484-22
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Cross-Species Permissivity: Structure of a Goat Adeno-Associated Virus and Its Complex with the Human Receptor AAVR
Journal article published in 2022 by
Edward E. Large,
Mark A. Silveria,
Onellah Weerakoon,
Tommi A. White,
Michael S. Chapman 
,
Colin R. Parrish
,
Colin R. Parrish
This paper is made freely available by the publisher.
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Abstract
Adeno-associated virus (AAV) is a small ssDNA satellite parvovirus. As a recombinant vector with a protein shell encapsidating a transgene, recombinant AAV (rAAV) is a leading delivery vehicle for gene therapy, with two FDA-approved treatments and 150 clinical trials for 30 diseases.