AbstractWe perform nuclear magnetic resonance (NMR) measurements of the oxygen-17 Knight shifts for Sr₂RuO₄, while subjected to uniaxial stress applied along [100] direction. The resulting strain is associated with a strong variation of the temperature and magnetic field dependence of the inferred magnetic response. A quasiparticle description based on density-functional theory calculations, supplemented by many-body renormalizations, is found to reproduce our experimental results, and highlights the key role of a van-Hove singularity. The Fermi-liquid coherence scale is shown to be tunable by strain, and driven to low values as the associated Lifshitz transition is approached.