Published in
American Society for Microbiology, Infection and Immunity, 1(91), 2023
DOI: 10.1128/iai.00361-22
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Mouse α-Defensins: Structural and Functional Analysis of the 17 Cryptdin Isoforms Identified from a Single Jejunal Crypt
Journal article published in 2023 by
Qingxia Wang,
Yilin Yang,
Gan Luo,
Yang Zhou,
William D. Tolbert,
Marzena Pazgier 
,
Chongbing Liao,
Wuyuan Lu
,
Chongbing Liao,
Wuyuan Lu
This paper is made freely available by the publisher.
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Abstract
Mouse α-defensins, better known as cryptdins, are host protective antimicrobial peptides produced in the intestinal crypt by Paneth cells. To date, more than 20 cryptdin mRNAs have been identified from mouse small intestine, of which the first six cryptdins (Crp1 to Crp6) have been isolated and characterized at the peptide level.