Bentham Science Publishers, Current Organic Chemistry, (25), 2021
DOI: 10.2174/1385272825666210518124845
Bentham Science Publishers, Current Organic Chemistry, 11(25), p. 1321-1344, 2021
DOI: 10.2174/18755348mte1knjyj2
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: Oxindoles are an important class of heterocyclic scaffolds widely present in natural products and bioactive compounds. For this reason, a plethora of methodologies for the stereoselective synthesis of enantioenriched oxindoles has been studied over the years. Among all the reported synthetic strategies, organocatalysis has proven to be a powerful tool for the asymmetric synthesis of this class of compounds being a step- and atom-economical, environmentally friendly, and non-toxic approach. This review will outline the application of asymmetric organocatalysis in the synthesis of chiral oxindole-based structures, relying on domino/one-pot reaction sequences in a step-economical fashion.