Abstract A rising trend is being observed in enhancing Inter-Professional Education and Collaborative Practice (IPECP) in health care settings. Empirical evidence on its effects, particularly in youth settings, remains limited. This study examined the moderating role of inter-professional learning in the relation between youth work practitioners’ self-efficacy in social work and their creative self-efficacy and innovative behaviour. A total of 227 youth work practitioners from sixteen district-based youth services in Hong Kong were invited to participate in a survey. The results of regression analyses indicate a positive association between practitioners’ sense of self-efficacy in social work and their creative self-efficacy and innovative behaviour. They also show a positive association between practitioners’ inter-professional learning experience and their creative self-efficacy and innovative behaviour. However, concerning the interaction effect between self-efficacy in social work and inter-professional learning, the results indicate that the positive relationship between self-efficacy in social work and creative self-efficacy and innovative behaviour was weaker for practitioners who had a higher level of inter-professional learning. The promotion of IPECP and the preparation of social workers to be collaboration-ready were deemed essential in fostering an effective multi-agency and multi-profession partnership, especially for seasoned practitioners who were more likely to possess a silo mentality.