Published in
American Society for Microbiology, Journal of Virology, 1(97), 2023
DOI: 10.1128/jvi.01638-22
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Characterization of a Novel CD4 Mimetic Compound YIR-821 against HIV-1 Clinical Isolates
Journal article published in 2023 by
Kaho Matsumoto 
,
Takeo Kuwata,
William D. Tolbert,
Jonathan Richard,
Shilei Ding,
Jérémie Prévost,
Shokichi Takahama,
George P. Judicate,
Takamasa Ueno ,
Hirotomo Nakata,
Takuya Kobayakawa,
Kohei Tsuji,
Hirokazu Tamamura,
Amos B. Smith,
Marzena Pazgier
and other authors.
,
Takeo Kuwata,
William D. Tolbert,
Jonathan Richard,
Shilei Ding,
Jérémie Prévost,
Shokichi Takahama,
George P. Judicate,
Takamasa Ueno ,
Hirotomo Nakata,
Takuya Kobayakawa,
Kohei Tsuji,
Hirokazu Tamamura,
Amos B. Smith,
Marzena Pazgier
and other authors.
This paper is made freely available by the publisher.
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Abstract
Small CD4-mimetic compound (CD4mc) interacts with the Phe43 cavity and triggers conformational changes, enhancing antibody-mediated neutralization and antibody-dependent cellular cytotoxicity (ADCC). Here, we evaluated the effect of YIR-821, a novel CD4mc, against clinical isolates, including both subtype B and non-B subtype viruses.