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Oxford University Press, Open Forum Infectious Diseases, 12(9), 2022

DOI: 10.1093/ofid/ofac587

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Comparing Prospective Incident Severe Acute Respiratory Syndrome Coronavirus 2 Infection Rates During Successive Waves of Delta and Omicron in Johannesburg, South Africa

Journal article published in 2022 by Simiso Sokhela ORCID, Bronwyn Bosch, Andrew Hill, Bryony Simmons, Joana Woods, Hilary Johnstone, Shabir Madhi, Ambar Qavi ORCID, Leah Ellis, Godspower Akpomiemie, Esther Bhaskar, Jacob Levi ORCID, Jonathan Falconer, Manya Mirchandani, Carmen Perez Casas and other authors.
This paper is made freely available by the publisher.
This paper is made freely available by the publisher.

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Abstract

Abstract In high-risk individuals in Johannesburg, during the Delta coronavirus disease 2019 wave, 22% (125/561) were positive, with 33% symptomatic (2 hospitalizations; 1 death). During Omicron, 56% (232/411) were infected, with 24% symptomatic (no hospitalizations or deaths). The remarkable speed of infection of Omicron over Delta poses challenges to conventional severe acute respiratory syndrome coronavirus 2 control measures.