AIE polymers have been extensively researched in the fields of OLEDs, sensing, and cancer treatment since its first report in 2003, which have achieved numerous breakthroughs during the years. In comparison with small molecules, it can simultaneously combine the unique advantages of AIE materials and the polymer itself, to further enhance their corresponding photophysical performances. In this review, we enumerate and discuss the common construction strategies of AIE-active polymers and summarize the progress of research on polymerization enhancing luminescence, photosensitization, and room-temperature phosphorescence (RTP) with their related applications in chemo/bio-sensing and therapy. To conclude, we also discuss current challenges and prospects of the field for future development.