Published in
American Society for Microbiology, Antimicrobial Agents and Chemotherapy, 1(67), 2023
DOI: 10.1128/aac.01315-22
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Atypical Mutational Spectrum of SARS-CoV-2 Replicating in the Presence of Ribavirin
Journal article published in 2023 by
Pilar Somovilla,
Carlos García-Crespo,
Brenda Martínez-González,
María Eugenia Soria,
Ana Isabel de Ávila,
Isabel Gallego,
Pablo Mínguez,
Antoni Durán-Pastor,
Cristina Ferrer-Orta,
Llanos Salar-Vidal,
Mario Esteban-Muñoz,
Sonia Zuñiga,
Isabel Sola,
Luis Enjuanes 
,
Jaime Esteban
and other authors.
,
Jaime Esteban
and other authors.
This paper is made freely available by the publisher.
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Abstract
We report that ribavirin exerts an inhibitory and mutagenic activity on SARS-CoV-2-infecting Vero cells, with a therapeutic index higher than 10. Deep sequencing analysis of the mutant spectrum of SARS-CoV-2 replicating in the absence or presence of ribavirin indicated an increase in the number of mutations, but not in deletions, and modification of diversity indices, expected from a mutagenic activity.