Published in
American Society for Microbiology, Journal of Virology, 1(97), 2023
DOI: 10.1128/jvi.01359-22
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Suicidal Phenotype of Proofreading-Deficient Herpes Simplex Virus 1 Polymerase Mutants
Journal article published in 2023 by
Marika Brunialti,
Thomas Höfler 
,
Mariana Nascimento,
Jakob Trimpert
,
Mariana Nascimento,
Jakob Trimpert
This paper is made freely available by the publisher.
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Abstract
Recovery of fully exonuclease-deficient herpes simplex virus 1 (HSV-1) DNA polymerase mutants has been so far unsuccessful. However, exonuclease activity is not known to be directly essential for virus replication, and the lethal phenotype of certain HSV-1 polymerase mutants is thus attributed to factors other than exonuclease activity.