Published in

American Physiological Society, American Journal of Physiology - Heart and Circulatory Physiology, 2(324), p. H241-H257, 2023

DOI: 10.1152/ajpheart.00390.2022

Links

Tools

Export citation

Search in Google Scholar

A high-sucrose diet exacerbates the left ventricular phenotype in a high fat-fed streptozotocin rat model of diabetic cardiomyopathy

Journal article published in 2023 by Anida Velagic, Mandy Li ORCID, Minh Deo, Jasmin Chendi Li, Helen Kiriazis, Daniel G. Donner ORCID, Dovile Anderson, Miles J. De Blasio, Owen L. Woodman ORCID, Barbara K. Kemp-Harper ORCID, Cheng Xue Qin, Rebecca H. Ritchie ORCID
This paper was not found in any repository, but could be made available legally by the author.
This paper was not found in any repository, but could be made available legally by the author.

Full text: Unavailable

Green circle
Preprint: archiving allowed
Upload
Orange circle
Postprint: archiving restricted
Upload
Red circle
Published version: archiving forbidden
Policy details
Data provided by SHERPA/RoMEO

Abstract

Left ventricular dysfunction and adverse remodeling were more pronounced in diabetic rats that received low-dose streptozotocin (STZ) and a high-sucrose high-fat diet (HFD) compared with those on a moderate-sucrose HFD in combination with STZ. Our findings highlight the importance of sucrose content in diet composition, particularly in preclinical studies of diabetic cardiomyopathy, and demonstrate that low-dose STZ combined with a high-sucrose HFD is an appropriate rodent model of cardiomyopathy in type 2 diabetes.